HitPredict

Interactor 1: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Interactor 2: ERB1 (Q04660)
Ribosome biogenesis protein ERB1 (Eukaryotic ribosome biogenesis protein 1)
Gene: ERB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	11805837, 16429126, 30568249, 36929751, 37968396, 37811893, 21825077
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BOP1NT~DUF4217
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0030687 - preribosome, large subunit precursor
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 606 Sc			1 807
+	Sc
		976852 HAS1_YEAST (6-467): 1.01e-156: 460: 30.98		ERB1_YEAST (1-807): 0: 587: 100.00
+	Dm
		1178811 DDX18_DROME (6-481): 1.03e-152: 457: 28.96		BOP1_DROME (9-806): 1e-174: 524: 36.92
+	Sc
		699727 DRS1_YEAST (21-392): 3.9e-47: 178: 31.75		ERB1_YEAST (1-807): 0: 587: 100.00
+	Hs
		903549 DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		903327 DDX46_HUMAN (2-597): 8.55e-134: 418: 21.15		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Sc
		630886 HAS1_YEAST (6-467): 1.01e-156: 460: 30.98		NLE1_YEAST (676-807): 3.44e-28: 121: 16.43
+	Sc
		630846 SPB4_YEAST (1-606): 2.46e-149: 445: 100.00		NLE1_YEAST (676-807): 3.44e-28: 121: 16.43
+	Hs
		903410 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		571382 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		133956 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		1271679 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		NLE1_HUMAN (706-806): 8.16e-21: 98.6: 17.82
+	Hs
		1271615 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		FBXW7_HUMAN (717-807): 4.36e-11: 68.6: 22.83
+	Hs
		134154 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		FBXW7_HUMAN (717-807): 4.36e-11: 68.6: 22.83
+	Hs
		903507 DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		209494 DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95		PLRG1_HUMAN (581-806): 1.32e-46: 176: 14.90
+	Sc
		630853 DRS1_YEAST (21-392): 3.9e-47: 178: 31.75		NLE1_YEAST (676-807): 3.44e-28: 121: 16.43
+	Hs
		1281463 DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95		FBXW7_HUMAN (717-807): 4.36e-11: 68.6: 22.83