HitPredict

Interactor 1: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Interactor 2: YTM1 (Q12024)
Ribosome biogenesis protein YTM1 (Microtubule-associated protein YTM1)
Gene: YTM1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	16429126, 36929751, 30568249, 37968396, 37811893, 21825077
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0030687 - preribosome, large subunit precursor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Sc			1 460
+	Sc
		976885 HAS1_YEAST (6-467): 1.01e-156: 460: 30.98		YTM1_YEAST (1-460): 5.89e-107: 326: 100.00
+	Hs
		1271615 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		FBXW7_HUMAN (190-457): 6.72e-60: 209: 18.38
+	Hs
		134154 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		FBXW7_HUMAN (190-457): 6.72e-60: 209: 18.38
+	Hs
		903549 DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49
+	Hs
		1288337 DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61		SNR40_HUMAN (362-459): 4.27e-15: 78.2: 18.18
+	Sc
		630886 HAS1_YEAST (6-467): 1.01e-156: 460: 30.98		NLE1_YEAST (19-130): 2.91e-11: 67.5: 15.28
+	Sc
		624089 DBP2_YEAST (2-402): 7.47e-126: 383: 25.43		MET30_YEAST (137-452): 3.86e-34: 137: 19.26
+	Sc
		630846 SPB4_YEAST (1-606): 2.46e-149: 445: 100.00		NLE1_YEAST (19-130): 2.91e-11: 67.5: 15.28
+	Hs
		903327 DDX46_HUMAN (2-597): 8.55e-134: 418: 21.15		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49
+	Hs
		1271700 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		FBW1A_HUMAN (101-246): 3.17e-19: 92.2: 19.65
+	Hs
		1271679 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		NLE1_HUMAN (362-459): 3.92e-19: 91.7: 24.24
+	Hs
		571638 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		FBW1A_HUMAN (101-246): 3.17e-19: 92.2: 19.65
+	Hs
		903410 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49
+	Hs
		1271621 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		SNR40_HUMAN (362-459): 4.27e-15: 78.2: 18.18
+	Hs
		571382 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49
+	Hs
		571547 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		SNR40_HUMAN (362-459): 4.27e-15: 78.2: 18.18
+	Hs
		134256 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		FBW1A_HUMAN (101-246): 3.17e-19: 92.2: 19.65
+	Hs
		133956 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49
+	Hs
		134246 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		FBW1B_HUMAN (116-451): 1.16e-10: 65.5: 26.61
+	Hs
		903507 DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35		WDR5_HUMAN (362-458): 1.09e-16: 82.9: 24.49