HitPredict

Interactor 1: S100P (P25815)
Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)
Gene: S100P

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	14617629, 16061848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region GO:0044548 - S100 protein binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 95 Hs			1 404
+	Rn
		385826 S100B_RAT (1-92): 5.88e-31: 106: 48.91		RAGE_RAT (1-404): 1.03e-73: 237: 77.97
+	Hs
		615216 S10A1_HUMAN (2-93): 1.61e-35: 117: 53.26		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		642944 S10A4_HUMAN (3-95): 3.19e-33: 112: 41.94		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		380779 S100B_HUMAN (1-92): 1.7e-31: 107: 50.00		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		946195 S10AC_HUMAN (1-92): 2.21e-30: 104: 44.57		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		793247 S10AA_HUMAN (2-89): 2.29e-30: 104: 44.32		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		639033 S100P_HUMAN (1-95): 3.03e-36: 119: 100.00		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		642975 S10A4_HUMAN (3-95): 3.19e-33: 112: 41.94		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		661374 S10A2_HUMAN (2-95): 5.21e-32: 109: 40.43		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42