HitPredict

Interactor 1: CKB11 (P25859)
Cyclin-dependent kinase B1-1 (CDKB1;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog B)
Gene: CDKB1-1

Interactor 2: CCD41 (Q8LGA1)
Cyclin-D4-1 (G1/S-specific cyclin-D4-1) (CycD4;1)
Gene: CYCD4-1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.860

Property	Details
Experiments	12857813, 20407024, 20706207
Identification Methods	pull down, protein complementation assay, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 At			1 308
+	At
		1103366 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA24_ARATH (23-308): 1.3e-91: 281: 17.83
+	At
		1103349 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA23_ARATH (17-308): 5.59e-91: 279: 19.52
+	At
		1103352 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA21_ARATH (10-308): 2.06e-90: 278: 21.41
+	At
		1103369 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA31_ARATH (16-306): 2.27e-90: 274: 18.56
+	Hs
		538471 CDK2_HUMAN (1-307): 1.5e-139: 397: 53.25		CCNB1_HUMAN (2-308): 7.01e-88: 271: 13.10
+	At
		1059417 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA22_ARATH (7-308): 3.36e-86: 266: 18.54
+	At
		1103353 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCA34_ARATH (26-306): 6.14e-85: 261: 19.37
+	At
		1103360 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCD41_ARATH (1-308): 1.87e-85: 260: 100.00
+	Hs
		303829 CDK2_HUMAN (1-307): 1.5e-139: 397: 53.25		CCNB2_HUMAN (2-308): 2.22e-84: 261: 17.36
+	At
		1103371 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCB23_ARATH (1-300): 3.46e-82: 256: 18.00
+	At
		1103350 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCB12_ARATH (25-294): 2.74e-78: 246: 17.78
+	At
		672516 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCB11_ARATH (18-305): 8.52e-77: 242: 18.34
+	At
		1103351 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCB22_ARATH (24-308): 1.03e-73: 234: 16.14
+	At
		1013000 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCD42_ARATH (8-286): 6.61e-73: 228: 69.53
+	Rn
		981205 Q6P751_RAT (1-307): 2.57e-139: 397: 53.25		CCND2_RAT (8-280): 4.29e-73: 228: 28.11
+	At
		1103376 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCB31_ARATH (15-279): 1.24e-69: 222: 18.49
+	Rn
		70081 Q6P751_RAT (1-307): 2.57e-139: 397: 53.25		B1WC54_RAT (6-244): 1.42e-60: 200: 21.57
+	At
		1103315 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCD51_ARATH (1-268): 5.74e-61: 198: 28.72
+	At
		1103379 CKB12_ARATH (1-309): 1.09e-139: 398: 87.78		CCD61_ARATH (41-303): 1.33e-60: 196: 30.04
+	Hs
		331629 CDK2_HUMAN (1-307): 1.5e-139: 397: 53.25		CCNE2_HUMAN (33-283): 1.26e-55: 186: 25.10