HitPredict

Interactor 1: UBCD1 (P25867)
Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: eff

Interactor 2: LUBEL (Q8IPJ3)
E3 ubiquitin-protein ligase lubel (EC 2.3.2.31) (Linear Ubiquitin E3 ligase)
Gene: LUBEL

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	27702987
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~UQ_con, IBR~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0097039 - protein linear polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Dm			1 2892
+	Mm
		895978 UB2D3_MOUSE (1-147): 3.31e-81: 237: 93.88		RNF31_MOUSE (2258-2889): 2.63e-132: 447: 28.28
+	Hs
		849498 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		ARI1_HUMAN (2419-2885): 2.33e-133: 433: 18.33
+	Hs
		1290106 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04
+	Hs
		849403 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04
+	Hs
		919819 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04
+	Hs
		312679 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80
+	Hs
		312520 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80
+	Hs
		312553 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80
+	Hs
		312528 UB2D3_HUMAN (1-147): 3.31e-81: 237: 93.88		ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80
+	Hs
		1354303 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		RNF14_HUMAN (2403-2742): 1.07e-71: 251: 19.14
+	Hs
		849474 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		RNF14_HUMAN (2403-2742): 1.07e-71: 251: 19.14
+	Hs
		919876 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RN19A_HUMAN (2439-2793): 3.36e-68: 251: 18.43
+	Hs
		919891 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RNF14_HUMAN (2403-2742): 1.07e-71: 251: 19.14
+	Hs
		842095 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		R144A_HUMAN (2510-2754): 1.5e-72: 247: 20.47
+	Hs
		842104 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		R144A_HUMAN (2510-2754): 1.5e-72: 247: 20.47
+	Hs
		229121 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59
+	Hs
		226914 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59
+	Hs
		919757 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RN19B_HUMAN (2509-2765): 2.33e-65: 240: 21.85
+	Hs
		227093 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59
+	Hs
		227029 UB2D3_HUMAN (1-147): 3.31e-81: 237: 93.88		PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59