HitPredict

Interactor 1: UBCD1 (P25867)
Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: eff

Interactor 2: SINAL (Q8T3Y0)
Probable E3 ubiquitin-protein ligase sinah (EC 2.3.2.27) (RING-type E3 ubiquitin transferase sinah) (Sina homolog)
Gene: sinah

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	37061542, unassigned1513
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0045676 - regulation of R7 cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Dm			1 351
+	Hs
		1216737 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		SIAH1_HUMAN (71-345): 2.2e-104: 309: 46.07
+	Dm
		598811 UBCD1_DROME (1-147): 6.04e-82: 239: 100.00		SINA_DROME (90-346): 7.43e-105: 312: 53.10
+	Hs
		849364 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		SIAH1_HUMAN (71-345): 2.2e-104: 309: 46.07
+	Hs
		919778 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		SIAH1_HUMAN (71-345): 2.2e-104: 309: 46.07
+	Hs
		199099 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		SIAH2_HUMAN (32-344): 7.07e-99: 297: 40.31
+	Hs
		199105 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		SIAH2_HUMAN (32-344): 7.07e-99: 297: 40.31
+	Hs
		1163056 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		TRAF7_HUMAN (2-292): 5.95e-47: 170: 14.72
+	Hs
		849344 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		TRAF7_HUMAN (2-292): 5.95e-47: 170: 14.72
+	Hs
		919755 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		TRAF7_HUMAN (2-292): 5.95e-47: 170: 14.72
+	Mm
		895982 UB2D1_MOUSE (1-147): 1.19e-82: 241: 89.12		RNF41_MOUSE (94-230): 1.05e-35: 133: 22.76
+	Hs
		1377466 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		TRAF6_HUMAN (46-304): 1.24e-32: 129: 12.73
+	Hs
		849496 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		TRAF6_HUMAN (46-304): 1.24e-32: 129: 12.73
+	Hs
		584907 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		RO52_HUMAN (92-267): 1.95e-29: 119: 15.50
+	Hs
		919911 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		PZRN3_HUMAN (94-215): 3.56e-29: 120: 23.08
+	Hs
		584923 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RO52_HUMAN (92-267): 1.95e-29: 119: 15.50
+	Dm
		639403 UBCD1_DROME (1-147): 6.04e-82: 239: 100.00		Q9VJW5_DROME (100-214): 1.64e-30: 119: 23.58
+	Hs
		849427 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		TRAF4_HUMAN (90-216): 1.67e-27: 114: 21.48
+	Hs
		919736 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		RN151_HUMAN (96-215): 8.16e-27: 108: 22.84
+	Hs
		1377468 UB2D4_HUMAN (1-147): 2.83e-83: 242: 92.52		RN114_HUMAN (85-186): 2.33e-17: 81.8: 25.00
+	Hs
		849499 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		RN114_HUMAN (85-186): 2.33e-17: 81.8: 25.00