HitPredict

Interactor 1: UBCD1 (P25867)
Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)
Gene: eff

Interactor 2: Q9W1E5 (Q9W1E5)
Anaphase-promoting complex subunit 2
Gene: mr

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	19906849
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ANAPC2~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 147 Dm			1 802
+	Hs
		1041136 UB2E3_HUMAN (4-146): 1.83e-73: 219: 65.73		CUL1_HUMAN (110-794): 0: 591: 13.04
+	Dm
		639393 UBCD1_DROME (1-147): 6.04e-82: 239: 100.00		CUL1_DROME (111-794): 0: 560: 13.64
+	Hs
		919897 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		ANC2_HUMAN (58-802): 0: 558: 36.72
+	Hs
		849326 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		CUL4A_HUMAN (123-790): 0: 549: 13.38
+	Hs
		895791 UB2D3_HUMAN (1-147): 3.31e-81: 237: 93.88		CUL4A_HUMAN (123-790): 0: 549: 13.38
+	Hs
		849324 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		CUL2_HUMAN (121-784): 0: 539: 10.63
+	Hs
		895790 UB2D3_HUMAN (1-147): 3.31e-81: 237: 93.88		CUL2_HUMAN (121-784): 0: 539: 10.63
+	Hs
		849325 UB2D1_HUMAN (1-147): 1.19e-82: 241: 89.12		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		919724 UB2D2_HUMAN (1-147): 3.06e-82: 239: 94.56		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		1043149 UB2E3_HUMAN (4-146): 1.83e-73: 219: 65.73		CUL4A_HUMAN (123-790): 0: 549: 13.38
+	Hs
		895792 UB2D3_HUMAN (1-147): 3.31e-81: 237: 93.88		CUL4B_HUMAN (123-790): 6.41e-176: 531: 12.24
+	Hs
		1042304 UB2E2_HUMAN (4-146): 4.09e-74: 221: 65.73		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		1042223 UB2E3_HUMAN (4-146): 1.83e-73: 219: 65.73		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		851812 UB2E1_HUMAN (4-146): 5.46e-72: 215: 65.73		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	Hs
		828994 UBE2A_HUMAN (2-144): 7.67e-71: 211: 39.16		CUL4B_HUMAN (123-790): 6.41e-176: 531: 12.24
+	Hs
		896438 UBE2N_HUMAN (4-147): 5.62e-69: 206: 49.31		CUL3_HUMAN (103-791): 5.42e-179: 534: 12.04
+	At
		1228143 COP10_ARATH (4-146): 2.98e-58: 180: 58.04		CUL4_ARATH (104-791): 4.56e-168: 507: 13.41
+	Sp
		804458 UBC4_SCHPO (1-147): 1.62e-80: 235: 87.08		CUL3_SCHPO (490-694): 3.49e-37: 151: 21.50