HitPredict

Interactor 1: LYN (P25911)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: SH21C (Q45HK4)
SH2 domain-containing protein 1B2 (EAT-2-related transducer) (ERT) (EAT-2B)
Gene: Sh2d1b2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16425036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0002250 - adaptive immune response GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 512 Mm			1 132
+	Hs
		433216 LYN_HUMAN (1-512): 0: 612: 96.09		YES_HUMAN (4-127): 2.82e-36: 131: 23.85
+	Hs
		433530 LYN_HUMAN (1-512): 0: 612: 96.09		HCK_HUMAN (4-127): 1.04e-35: 130: 26.92
+	Hs
		433931 LYN_HUMAN (1-512): 0: 612: 96.09		SHIP1_HUMAN (5-132): 1.06e-34: 128: 28.91
+	Rn
		989767 LYN_RAT (1-512): 0: 613: 98.24		SRC_RAT (4-127): 7.7e-35: 127: 26.92
+	Hs
		176351 LYN_HUMAN (1-512): 0: 612: 96.09		SHIP2_HUMAN (5-102): 2.46e-34: 127: 40.82
+	Hs
		433546 LYN_HUMAN (1-512): 0: 612: 96.09		SRC_HUMAN (4-127): 9.53e-35: 127: 26.92
+	Hs
		411553 LYN_HUMAN (1-512): 0: 612: 96.09		LCK_HUMAN (4-127): 3.02e-34: 125: 26.92
+	Rn
		989763 LYN_RAT (1-512): 0: 613: 98.24		LYN_RAT (4-126): 7.53e-34: 124: 22.48
+	Hs
		433522 LYN_HUMAN (1-512): 0: 612: 96.09		LYN_HUMAN (4-126): 1.08e-33: 124: 22.48
+	Hs
		433535 LYN_HUMAN (1-512): 0: 612: 96.09		FGR_HUMAN (4-126): 3.54e-33: 123: 23.26
+	Hs
		433653 LYN_HUMAN (1-512): 0: 612: 96.09		BLK_HUMAN (1-127): 1.44e-33: 123: 24.06
+	Hs
		442759 HCK_HUMAN (1-512): 0: 599: 71.48		HCK_HUMAN (4-127): 1.04e-35: 130: 26.92
+	Hs
		442789 HCK_HUMAN (1-512): 0: 599: 71.48		ABL2_HUMAN (5-126): 3.99e-35: 129: 27.05
+	Hs
		243122 LYN_HUMAN (1-512): 0: 612: 96.09		SH21A_HUMAN (6-124): 1.35e-33: 115: 38.66
+	Hs
		337315 HCK_HUMAN (1-512): 0: 599: 71.48		ABL1_HUMAN (5-126): 9.52e-35: 128: 26.23
+	Hs
		442772 HCK_HUMAN (1-512): 0: 599: 71.48		SRC_HUMAN (4-127): 9.53e-35: 127: 26.92
+	Hs
		411559 HCK_HUMAN (1-512): 0: 599: 71.48		LCK_HUMAN (4-127): 3.02e-34: 125: 26.92
+	Hs
		433635 LYN_HUMAN (1-512): 0: 612: 96.09		KSYK_HUMAN (3-128): 4.23e-16: 75.1: 25.98
+	Mm
		639437 LYN_MOUSE (1-512): 0: 613: 100.00		KSYK_MOUSE (3-128): 1e-14: 71.2: 25.20