HitPredict

Interactor 1: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	20614026, 9718306, 17332487, 10318845
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0065003 - protein-containing complex assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 277 Hs			1 416
+	Hs
		1023848 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		639576 TNR5_HUMAN (1-277): 4.35e-85: 257: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		648951 TNR5_MOUSE (1-277): 2.29e-81: 248: 60.43		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Mm
		192583 TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		639668 TNR5_HUMAN (1-277): 4.35e-85: 257: 100.00		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Mm
		761824 TNR14_MOUSE (8-256): 3.56e-60: 193: 29.64		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		1021008 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		648955 TNR5_MOUSE (1-277): 2.29e-81: 248: 60.43		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		591317 TNR1B_HUMAN (12-234): 1.42e-53: 181: 30.26		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		192585 TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		1377881 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		129532 TNR5_HUMAN (1-277): 4.35e-85: 257: 100.00		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		639578 TNR5_HUMAN (1-277): 4.35e-85: 257: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Mm
		648958 TNR5_MOUSE (1-277): 2.29e-81: 248: 60.43		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37
+	Hs
		639638 TNR5_HUMAN (1-277): 4.35e-85: 257: 100.00		TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86
+	Hs
		129607 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Mm
		192584 TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Mm
		192587 TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37
+	Mm
		936208 TNR14_MOUSE (8-256): 3.56e-60: 193: 29.64		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Hs
		1024798 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77