HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32912968, 15536134
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0051059 - NF-kappaB binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 488
+	Hs
		639742 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140230 NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		961382 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		257678 ANR17_HUMAN (20-307): 2.66e-38: 146: 13.27		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177199 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		292423 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		587651 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		292405 NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		1219802 ANKH1_HUMAN (4-107): 2.55e-18: 87.9: 6.73		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		257609 ANR17_HUMAN (20-307): 2.66e-38: 146: 13.27		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		595672 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		587561 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		166921 ANR28_HUMAN (3-94): 1.78e-12: 69.8: 7.45		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177194 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		177192 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		638477 NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98		HDAC6_MOUSE (11-367): 2.93e-104: 338: 24.12
+	Mm
		1157667 TNKS1_MOUSE (187-313): 2.9e-30: 122: 18.75		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		1157665 CSKI1_MOUSE (175-314): 1.4e-21: 97.3: 19.29		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		56845 TANC2_MOUSE (3-181): 3.02e-21: 96.6: 17.88		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		595686 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04