HitPredict

Interactor 1: PTN3 (P26045)
Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)
Gene: PTPN3

Interactor 2: MK12 (P53778)
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
Gene: MAPK12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.648

The method score is based on:

Property Details
Experiments 20332238, 25728925
Identification Methods two hybrid, pull down, affinity chromatography technology, enzymatic study, phosphatase assay
Interaction Type direct interaction, physical association, association, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000165 - MAPK cascade
GO:0005737 - cytoplasm
GO:0005829 - cytosol
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 913
Hs

1 367
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024