HitPredict

Interactor 1: PSMD7 (P26270)
26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Proteasome subunit p39B) (Proteasome subunit p40) (Protein Mov34)
Gene: Rpn8

Interactor 2: PSMD1 (Q9V3P6)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory complex subunit p110) (26S proteasome regulatory subunit RPN2)
Gene: Rpn2

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~PC_rep, HEAT_2~MitMem_reg
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005838 - proteasome regulatory particle GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 338 Dm			1 1020
+	Hs
		849257 PSMD7_HUMAN (4-288): 8.69e-104: 309: 81.75		PSMD1_HUMAN (3-1001): 0: 1176: 60.30
+	Hs
		696 PSMD7_HUMAN (4-288): 8.69e-104: 309: 81.75		A0A087WW66_HUMAN (3-1001): 0: 1100: 57.50
+	Dm
		1358666 PSDE_DROME (2-273): 9.64e-61: 198: 16.89		PSMD1_DROME (1-1004): 0: 1198: 100.00
+	Hs
		131053 PSDE_HUMAN (2-275): 4.37e-61: 199: 16.78		PSMD1_HUMAN (3-1001): 0: 1176: 60.30
+	Sc
		693372 RPN8_YEAST (9-312): 1.24e-91: 278: 46.27		RPN2_YEAST (1-1016): 0: 950: 35.74
+	Sp
		251846 RPN11_SCHPO (3-272): 2.41e-61: 199: 18.00		RPN2_SCHPO (3-1017): 0: 1018: 42.27
+	Hs
		849192 PSMD7_HUMAN (4-288): 8.69e-104: 309: 81.75		PSMD2_HUMAN (9-812): 0: 757: 16.90
+	Dm
		640795 PSMD7_DROME (1-338): 4.57e-136: 391: 100.00		Q9VW54_DROME (13-812): 0: 617: 17.03
+	Hs
		130871 PSDE_HUMAN (2-275): 4.37e-61: 199: 16.78		PSMD2_HUMAN (9-812): 0: 757: 16.90
+	At
		188942 PSD7A_ARATH (4-297): 2.79e-105: 312: 57.63		PSD2A_ARATH (9-812): 0: 624: 15.16
+	At
		1320083 PSD7B_ARATH (4-297): 1.8e-104: 310: 56.95		PSD2A_ARATH (9-812): 0: 624: 15.16
+	Sp
		251461 RPN8_SCHPO (1-311): 2.71e-100: 300: 47.71		RPN1_SCHPO (9-810): 0: 574: 16.86
+	At
		1339597 PSDE_ARATH (3-273): 1.72e-65: 210: 17.43		PSD2A_ARATH (9-812): 0: 624: 15.16
+	Dm
		1358676 PSDE_DROME (2-273): 9.64e-61: 198: 16.89		Q9VW54_DROME (13-812): 0: 617: 17.03
+	Sp
		784766 RPN11_SCHPO (3-272): 2.41e-61: 199: 18.00		RPN1_SCHPO (9-810): 0: 574: 16.86
+	Sc
		753971 RPN8_YEAST (9-312): 1.24e-91: 278: 46.27		RPN1_YEAST (9-619): 8.39e-106: 355: 14.66