HitPredict

Interactor 1: CPS4L (A6NMK7)
Putative cleavage and polyadenylation specificity factor subunit 4-like protein
Gene: CPSF4L

Interactor 2: CPSF3 (Q9UKF6)
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)
Gene: CPSF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0046872 - metal ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 179 Hs			1 684
+	Hs
		317873 CPSF4_HUMAN (1-177): 4.02e-67: 207: 64.41		CPSF3_HUMAN (1-684): 0: 803: 100.00
+	Sp
		142963 YTH1_SCHPO (65-178): 3.23e-36: 125: 50.00		YSH1_SCHPO (5-682): 0: 649: 46.82
+	Hs
		317868 CPSF4_HUMAN (1-177): 4.02e-67: 207: 64.41		CPSF2_HUMAN (12-640): 8.58e-180: 532: 19.17
+	Sc
		985883 YTH1_YEAST (1-167): 6.65e-42: 141: 36.00		YSH1_YEAST (4-683): 0: 589: 38.83
+	At
		69150 CPSF_ARATH (7-144): 7.69e-36: 132: 34.29		CPS3B_ARATH (12-566): 2.29e-165: 490: 29.42
+	Hs
		1135523 ZC3HA_HUMAN (66-145): 1.86e-14: 72.1: 18.70		INT11_HUMAN (10-616): 0: 538: 32.05
+	At
		69168 CPSF_ARATH (7-144): 7.69e-36: 132: 34.29		CPSF2_ARATH (9-564): 4.62e-115: 364: 18.37
+	Sc
		985885 YTH1_YEAST (1-167): 6.65e-42: 141: 36.00		CFT2_YEAST (18-483): 4.75e-77: 265: 15.96
+	Sp
		251804 YTH1_SCHPO (65-178): 3.23e-36: 125: 50.00		CFT2_SCHPO (27-373): 7.13e-81: 275: 23.50