HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 19173286
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BAH~BAH, BAH~DNA_methylase, DNA_methylase~DNA_methylase, DNA_methylase~DNMT1-RFD, DNA_methylase~zf-CXXC, zf-CXXC~zf-CXXC
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001674 - female germ cell nucleus
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003886 - DNA (cytosine-5-)-methyltransferase activity
and 21 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1616
Hs

1 1616
+ Mm
+ Hs
+ Hs
+ Xl
+ Hs
+ Dm
+ Xl
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm

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Last updated: 15 Jul 2024