HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12711675
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Chromo~DNA_methylase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1616 Hs			1 185
+	Hs
		641207 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		641165 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		203628 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		315971 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CBX6_HUMAN (12-101): 1.25e-25: 103: 30.00
+	Hs
		1027303 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949904 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		800543 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		1027214 MINT_HUMAN (5-706): 1.98e-35: 150: 12.71		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949925 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Dm
		399045 Q9VKB3_DROME (1139-1371): 3.2e-48: 178: 19.09		HP1_DROME (1-176): 7.89e-50: 161: 42.23
+	Hs
		800563 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		203801 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		1027054 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949814 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		123345 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Mm
		291745 DNM3B_MOUSE (1124-1325): 1.81e-39: 161: 18.52		CBX2_MOUSE (10-110): 1.42e-25: 104: 29.70
+	Hs
		800421 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		203822 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		123351 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	At
		1276954 CMT3_ARATH (656-924): 1.39e-21: 104: 13.82		LHP1_ARATH (17-109): 1.07e-14: 72.9: 34.04