HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: KAT2B (Q92831)
Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
Gene: KAT2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21947282
Identification Methods	acetylase assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 832
+	Hs
		641298 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		BAZ2A_HUMAN (698-826): 7.81e-38: 155: 35.66
+	Hs
		631349 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		BRD2_HUMAN (663-830): 1.89e-35: 146: 23.37
+	Hs
		641223 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		BRD3_HUMAN (672-830): 6.16e-33: 138: 22.67
+	Hs
		243961 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		BRD4_HUMAN (680-832): 1.99e-31: 134: 22.15
+	Xl
		945500 P79922_XENLA (126-1616): 0: 1502: 70.07		BRD4B_XENLA (664-832): 1.78e-31: 134: 20.12
+	Hs
		631488 PB1_HUMAN (42-1162): 0: 602: 15.37		BRD2_HUMAN (663-830): 1.89e-35: 146: 23.37
+	Hs
		1067030 PB1_HUMAN (42-1162): 0: 602: 15.37		BRD3_HUMAN (672-830): 6.16e-33: 138: 22.67
+	Hs
		244619 PB1_HUMAN (42-1162): 0: 602: 15.37		BRD4_HUMAN (680-832): 1.99e-31: 134: 22.15
+	Hs
		1199169 PB1_HUMAN (42-1162): 0: 602: 15.37		PHIP_HUMAN (683-826): 5.4e-15: 81.7: 24.49
+	Dm
		844325 Q9VC36_DROME (243-1099): 4.48e-111: 391: 11.16		TAF1_DROME (717-811): 8.72e-11: 68.2: 34.34
+	Hs
		1353937 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		BAZ2A_HUMAN (698-826): 7.81e-38: 155: 35.66
+	Hs
		170514 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		TIF1A_HUMAN (641-827): 1.04e-38: 157: 22.22
+	Hs
		245103 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		BRD4_HUMAN (680-832): 1.99e-31: 134: 22.15
+	Hs
		1199219 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		PB1_HUMAN (683-826): 4.92e-18: 91.8: 22.00
+	Hs
		1067006 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		BRD3_HUMAN (672-830): 6.16e-33: 138: 22.67
+	Hs
		244571 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		BRD4_HUMAN (680-832): 1.99e-31: 134: 22.15