HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.985

Property	Details
Experiments	26496610, 25960197, 30367141, 30804394, 31130994, 36264362, 36734974, 19615732, 21745816, 21268065, 21045206, 32884836, 22411829, 25753001
Identification Methods	affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BAH~USP7_ICP0_bdg, DNA_methylase~USP7_C2, DNA_methylase~USP7_ICP0_bdg
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0044027 - negative regulation of gene expression via chromosomal CpG island methylation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 1102
+	Hs
		1123947 Q59FP7_HUMAN (14-1616): 0: 1698: 99.75		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Xl
		945426 P79922_XENLA (126-1616): 0: 1502: 70.07		Q08B28_XENLA (2-529): 5.64e-172: 517: 94.89
+	Hs
		1199178 PB1_HUMAN (42-1162): 0: 602: 15.37		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273997 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1199208 PB1_HUMAN (42-1162): 0: 602: 15.37		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13