HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26641092
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 551
+	Hs
		1077379 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1054348 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		641856 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Mm
		857339 TIA1_MOUSE (253-475): 4.2e-36: 139: 15.70		CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62
+	Hs
		641756 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		1077418 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516364 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1031344 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		1020249 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516484 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1031328 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		1077489 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Zm
		8143 A0A1D6ELH4_MAIZE (87-419): 6.02e-48: 176: 15.27		A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55
+	Hs
		516518 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Mm
		665745 TIA1_MOUSE (253-475): 4.2e-36: 139: 15.70		PABP1_MOUSE (81-518): 3.65e-24: 108: 16.63
+	Hs
		516471 TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1031490 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516730 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516495 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		963541 TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67		LFG1_HUMAN (272-366): 2.55e-09: 61.1: 33.33