HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 261
+	Hs
		266913 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Mm
		641999 U2AF2_MOUSE (1-475): 2.34e-94: 295: 99.79		SRSF3_MOUSE (1-92): 1.68e-23: 95: 32.61
+	Hs
		641718 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		641724 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SRSF2_HUMAN (4-90): 1.12e-22: 94.6: 45.65
+	Hs
		641756 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516364 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Mm
		641996 U2AF2_MOUSE (1-475): 2.34e-94: 295: 99.79		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Hs
		1077426 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		PPIL4_HUMAN (6-254): 6.19e-32: 124: 17.32
+	Hs
		266976 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		641807 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Mm
		936689 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		SRSF7_MOUSE (4-109): 2.41e-23: 97.3: 32.08
+	Mm
		936671 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		SRSF3_MOUSE (1-92): 1.68e-23: 95: 32.61
+	Hs
		1031344 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		951937 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		1020249 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516484 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Mm
		936687 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		Q80ZW7_MOUSE (5-98): 5.84e-18: 84.1: 17.02
+	Hs
		963526 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		TIAR_HUMAN (4-98): 1.93e-17: 82.5: 16.84
+	Mm
		857310 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Hs
		680455 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		TIA1_HUMAN (5-99): 8.75e-17: 80.9: 17.90