HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	21536736, 26641092
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000245 - spliceosomal complex assembly GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 504
+	Hs
		1054665 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		641882 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Sp
		144103 U2AF2_SCHPO (49-472): 6.44e-73: 240: 29.32		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Hs
		641889 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		196958 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		197022 SART3_HUMAN (10-377): 4.33e-86: 285: 22.52		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		641697 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903236 SART3_HUMAN (10-377): 4.33e-86: 285: 22.52		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		1054489 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		1077517 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		NLE1_HUMAN (93-333): 6.85e-38: 146: 14.86
+	Hs
		1054500 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Dm
		1098209 U2AF2_DROME (84-474): 6.66e-70: 230: 68.35		Q7KLW9_DROME (26-336): 2.38e-31: 128: 13.52
+	Hs
		1281457 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		197019 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		903585 PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903196 PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		516438 PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48