HitPredict

Interactor 1: UBP27 (A6NNY8)
Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)
Gene: USP27X

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	27013495, 29576527
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 438 Hs			1 685
+	Hs
		476579 UBP22_HUMAN (1-426): 2.45e-149: 436: 82.20		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476400 UBP42_HUMAN (28-436): 1.94e-106: 344: 23.26		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475440 UBP8_HUMAN (8-419): 1.92e-106: 341: 26.14		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		271022 UBP2_HUMAN (2-419): 2.38e-110: 339: 28.09		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476493 UBP36_HUMAN (78-436): 2.21e-104: 335: 24.38		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475932 U17L2_HUMAN (8-431): 5.01e-109: 333: 26.27		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476658 UBP3_HUMAN (2-430): 2.68e-101: 313: 29.07		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476545 UBP21_HUMAN (76-419): 5.22e-100: 311: 26.96		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477538 NOT_DROME (2-426): 1.31e-111: 338: 51.24		UBIQP_DROME (1-610): 0: 752: 99.84
+	At
		1210479 UBP15_ARATH (74-426): 5e-99: 318: 26.05		UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80
+	Sc
		477366 UBP8_YEAST (76-419): 5.15e-102: 313: 32.23		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		1092065 UBP15_ARATH (74-426): 5e-99: 318: 26.05		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		924201 UBP36_HUMAN (78-436): 2.21e-104: 335: 24.38		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		476865 UBP8_MOUSE (8-419): 5.97e-105: 336: 25.46		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		1137288 UBP2_RAT (4-419): 8.17e-109: 335: 26.86		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		271114 UBP2_HUMAN (2-419): 2.38e-110: 339: 28.09		Q5U5U6_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		476893 UBP47_MOUSE (5-438): 9.56e-96: 315: 18.07		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476939 UBP3_MOUSE (2-430): 3.66e-100: 310: 28.85		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		398134 UBP21_HUMAN (76-419): 5.22e-100: 311: 26.96		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Mm
		477008 UBP12_MOUSE (77-422): 1.16e-95: 293: 24.73		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74