HitPredict

Interactor 1: SL9A1 (P26431)
Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
Gene: Slc9a1

Interactor 2: CHP2 (Q810D1)
Calcineurin B homologous protein 2 (Chp-2)
Gene: CHP2

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	12576672
Identification Methods	far western blotting, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~NEXCaM_BD
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006883 - intracellular sodium ion homeostasis GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070886 - positive regulation of calcineurin-NFAT signaling cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 820 Rn			1 196
+	Rn
		642812 SL9A1_RAT (1-820): 0: 876: 100.00		CHP1_RAT (1-195): 2.22e-43: 145: 60.00
+	Hs
		212564 SL9A1_HUMAN (1-820): 0: 854: 92.93		CHP2_HUMAN (1-196): 1.12e-47: 156: 81.63
+	Hs
		586058 SL9A1_HUMAN (1-820): 0: 854: 92.93		CHP3_HUMAN (12-195): 1.13e-43: 146: 29.27
+	Hs
		586063 SL9A1_HUMAN (1-820): 0: 854: 92.93		CHP1_HUMAN (1-195): 1.04e-43: 145: 60.51
+	Rn
		822755 SL9A2_RAT (65-804): 0: 691: 47.16		CHP2_RAT (1-196): 5.06e-45: 149: 100.00
+	Rn
		822754 SL9A2_RAT (65-804): 0: 691: 47.16		CHP1_RAT (1-195): 2.22e-43: 145: 60.00
+	Hs
		212574 SL9A2_HUMAN (89-804): 0: 674: 48.06		CHP2_HUMAN (1-196): 1.12e-47: 156: 81.63
+	Hs
		1305458 SL9A2_HUMAN (89-804): 0: 674: 48.06		CHP1_HUMAN (1-195): 1.04e-43: 145: 60.51
+	Hs
		212565 SL9A3_HUMAN (85-811): 0: 643: 38.90		CHP2_HUMAN (1-196): 1.12e-47: 156: 81.63
+	Hs
		822764 SL9A3_HUMAN (85-811): 0: 643: 38.90		CHP1_HUMAN (1-195): 1.04e-43: 145: 60.51
+	Rn
		642816 SL9A3_RAT (76-811): 0: 637: 37.53		CHP2_RAT (1-196): 5.06e-45: 149: 100.00
+	Rn
		642815 SL9A3_RAT (76-811): 0: 637: 37.53		CHP1_RAT (1-195): 2.22e-43: 145: 60.00
+	Hs
		212570 SL9A4_HUMAN (72-688): 0: 579: 46.54		CHP2_HUMAN (1-196): 1.12e-47: 156: 81.63
+	Hs
		1149580 SL9A4_HUMAN (72-688): 0: 579: 46.54		CHP1_HUMAN (1-195): 1.04e-43: 145: 60.51
+	Rn
		642819 SL9A4_RAT (71-688): 0: 575: 45.18		CHP2_RAT (1-196): 5.06e-45: 149: 100.00
+	Rn
		642818 SL9A4_RAT (71-688): 0: 575: 45.18		CHP1_RAT (1-195): 2.22e-43: 145: 60.00
+	Hs
		212568 SL9A5_HUMAN (93-717): 0: 546: 41.48		CHP2_HUMAN (1-196): 1.12e-47: 156: 81.63
+	Rn
		1194995 SL9A5_RAT (76-719): 0: 549: 40.30		CHP2_RAT (1-196): 5.06e-45: 149: 100.00
+	Rn
		895408 SL9A5_RAT (76-719): 0: 549: 40.30		CHP1_RAT (1-195): 2.22e-43: 145: 60.00
+	Hs
		1060400 SL9A5_HUMAN (93-717): 0: 546: 41.48		CHP1_HUMAN (1-195): 1.04e-43: 145: 60.51