HitPredict

Interactor 1: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Interactor 2: S10A2 (P29034)
Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)
Gene: S100A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0046914 - transition metal ion binding GO:0048306 - calcium-dependent protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 98
+	Hs
		1135040 Q5T7Y6_HUMAN (1-90): 5.35e-39: 128: 51.11		Q5T7Y6_HUMAN (2-91): 3.08e-40: 131: 52.22
+	Mm
		421245 S10A4_MOUSE (1-101): 1.46e-39: 128: 93.07		S10A4_MOUSE (2-97): 2.1e-39: 128: 61.46
+	Hs
		642915 S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00		S10A4_HUMAN (2-97): 2.05e-38: 125: 61.46
+	Mm
		421246 S10A4_MOUSE (1-101): 1.46e-39: 128: 93.07		S10A1_MOUSE (2-91): 2.19e-37: 122: 51.11
+	Hs
		615203 S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00		S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22
+	Hs
		615204 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S10A2_HUMAN (1-98): 9.73e-40: 128: 100.00
+	Hs
		638981 Q5T7Y6_HUMAN (1-90): 5.35e-39: 128: 51.11		S100P_HUMAN (4-92): 8.31e-36: 118: 42.70
+	Hs
		615200 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22
+	Hs
		615206 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S10A3_HUMAN (2-98): 3.78e-36: 119: 43.30
+	Hs
		685154 S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84		S10AB_HUMAN (2-97): 2.41e-36: 120: 29.90
+	Hs
		380790 Q5T7Y6_HUMAN (1-90): 5.35e-39: 128: 51.11		S100B_HUMAN (4-92): 8.65e-33: 111: 44.94
+	Hs
		615201 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S100P_HUMAN (4-92): 8.31e-36: 118: 42.70
+	Hs
		380739 S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00		S100B_HUMAN (4-92): 8.65e-33: 111: 44.94
+	Hs
		615222 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S100Z_HUMAN (2-91): 2.39e-34: 115: 43.33
+	Hs
		380736 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		S100B_HUMAN (4-92): 8.65e-33: 111: 44.94
+	Hs
		380745 S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84		S100B_HUMAN (4-92): 8.65e-33: 111: 44.94
+	Hs
		416574 S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00		S10A6_HUMAN (2-93): 1.75e-30: 104: 46.74
+	Hs
		1125327 HORN_HUMAN (1-96): 6.3e-33: 121: 25.74		FILA2_HUMAN (4-91): 2.11e-27: 105: 32.96