HitPredict

Interactor 1: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.589

Property	Details
Experiments	20591429
Identification Methods	pull down, surface plasmon resonance, molecular sieving, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 491
+	Hs
		615210 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		962851 HORN_HUMAN (1-96): 6.3e-33: 121: 25.74		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		661229 S10A2_HUMAN (1-97): 1.08e-35: 118: 60.83		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		380767 S100B_HUMAN (3-91): 3.86e-31: 106: 47.19		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		416609 S10A6_HUMAN (1-92): 1.7e-28: 100: 50.00		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		169240 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169242 S10A2_HUMAN (1-97): 1.08e-35: 118: 60.83		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169226 S100B_HUMAN (3-91): 3.86e-31: 106: 47.19		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169246 S10A5_HUMAN (1-90): 7.24e-25: 91: 53.33		MDM4_HUMAN (4-489): 0: 531: 32.08