HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: CRKL (P47941)
Crk-like protein
Gene: CRKL

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11031258
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0001934 - positive regulation of protein phosphorylation GO:0005829 - cytosol GO:0030971 - receptor tyrosine kinase binding GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 303
+	Hs
		655266 P85A_HUMAN (1-724): 0: 556: 94.35		CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70
+	Mm
		643099 P85A_MOUSE (1-724): 0: 566: 100.00		CRK_MOUSE (3-302): 1.23e-60: 196: 54.57
+	Hs
		655265 P85A_HUMAN (1-724): 0: 556: 94.35		CRK_HUMAN (3-302): 1.68e-60: 196: 54.57
+	Hs
		129238 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70
+	Mm
		643091 P85A_MOUSE (1-724): 0: 566: 100.00		GRB2_MOUSE (126-297): 5.09e-29: 112: 15.28
+	Hs
		580936 P85A_HUMAN (1-724): 0: 556: 94.35		PLCG1_HUMAN (3-202): 1.58e-29: 120: 19.44
+	Hs
		562627 P85A_HUMAN (1-724): 0: 556: 94.35		PLCG2_HUMAN (3-188): 3.83e-29: 119: 18.91
+	Mm
		140063 P85B_MOUSE (3-723): 3.36e-157: 474: 56.77		CRK_MOUSE (3-302): 1.23e-60: 196: 54.57
+	Hs
		129237 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		CRK_HUMAN (3-302): 1.68e-60: 196: 54.57
+	Hs
		655306 P85A_HUMAN (1-724): 0: 556: 94.35		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		548645 P85A_HUMAN (1-724): 0: 556: 94.35		VAV_HUMAN (213-293): 6.43e-17: 83.2: 30.49
+	Hs
		655439 P85A_HUMAN (1-724): 0: 556: 94.35		SH3K1_HUMAN (198-297): 3.86e-16: 80.5: 23.53
+	Hs
		655500 P85A_HUMAN (1-724): 0: 556: 94.35		VAV3_HUMAN (196-293): 4.65e-16: 80.5: 30.30
+	Hs
		557615 P85A_HUMAN (1-724): 0: 556: 94.35		NCK1_HUMAN (85-211): 8.85e-15: 75.7: 20.61
+	Hs
		129269 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		802683 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		CRK_HUMAN (3-302): 1.68e-60: 196: 54.57
+	Hs
		924735 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		557757 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		NCK1_HUMAN (85-211): 8.85e-15: 75.7: 20.61
+	Hs
		200212 SRGP3_HUMAN (83-453): 5.8e-69: 247: 15.43		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		1191674 SRGP1_HUMAN (86-459): 3.57e-65: 236: 16.01		SH3K1_HUMAN (198-297): 3.86e-16: 80.5: 23.53