HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: UFO (Q00993)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (Adhesion-related kinase)
Gene: Axl

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18346204
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 888
+	Hs
		655230 P85A_HUMAN (1-724): 0: 556: 94.35		UFO_HUMAN (1-888): 0: 760: 88.06
+	Mm
		643093 P85A_MOUSE (1-724): 0: 566: 100.00		MERTK_MOUSE (11-852): 0: 575: 40.96
+	Hs
		655220 P85A_HUMAN (1-724): 0: 556: 94.35		EPHA3_HUMAN (70-835): 0: 577: 21.26
+	Hs
		655222 P85A_HUMAN (1-724): 0: 556: 94.35		EPHB2_HUMAN (18-834): 0: 567: 20.64
+	Mm
		643085 P85A_MOUSE (1-724): 0: 566: 100.00		TIE2_MOUSE (9-802): 1.13e-173: 535: 22.45
+	Hs
		655219 P85A_HUMAN (1-724): 0: 556: 94.35		EPHA2_HUMAN (34-837): 9.62e-177: 538: 20.83
+	Mm
		936453 P70304_MOUSE (1-724): 0: 566: 99.86		EPHA2_MOUSE (34-837): 6.36e-171: 523: 19.93
+	Hs
		655221 P85A_HUMAN (1-724): 0: 556: 94.35		EPHA8_HUMAN (70-808): 1.69e-172: 528: 21.00
+	Mm
		643086 P85A_MOUSE (1-724): 0: 566: 100.00		TIE1_MOUSE (9-803): 2.93e-162: 505: 23.22
+	Hs
		600513 P85A_HUMAN (1-724): 0: 556: 94.35		EPHA1_HUMAN (70-836): 3.62e-156: 485: 21.40
+	Hs
		411306 P85A_HUMAN (1-724): 0: 556: 94.35		INSR_HUMAN (163-858): 2.1e-130: 426: 24.97
+	Hs
		441439 P85A_HUMAN (1-724): 0: 556: 94.35		MET_HUMAN (530-793): 2.05e-65: 241: 46.27
+	Mm
		546262 P85A_MOUSE (1-724): 0: 566: 100.00		INSR_MOUSE (343-801): 1.74e-59: 223: 32.35
+	Mm
		643062 P85A_MOUSE (1-724): 0: 566: 100.00		RET_MOUSE (495-826): 2.14e-56: 213: 36.49
+	Mm
		643057 P85A_MOUSE (1-724): 0: 566: 100.00		FAK1_MOUSE (521-845): 3.07e-55: 209: 36.83
+	Hs
		337356 P85A_HUMAN (1-724): 0: 556: 94.35		ABL1_HUMAN (525-802): 1.51e-55: 210: 44.44
+	Hs
		434140 P85A_HUMAN (1-724): 0: 556: 94.35		RET_HUMAN (495-801): 1.84e-55: 210: 37.20
+	Hs
		601463 P85A_HUMAN (1-724): 0: 556: 94.35		FGFR2_HUMAN (10-229): 1.11e-42: 169: 14.29
+	Hs
		435546 P85A_HUMAN (1-724): 0: 556: 94.35		IGF1R_HUMAN (224-389): 3.47e-12: 72.8: 17.58
+	Hs
		609182 P85A_HUMAN (1-724): 0: 556: 94.35		FGFR3_HUMAN (7-138): 8.97e-11: 67.8: 16.90