HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: Q3ZB59 (Q3ZB59)
Growth factor receptor bound protein 2-associated protein 2
Gene: Gab2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	10995764
Identification Methods	affinity chromatography technology, pull down, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 665
+	Hs
		655510 P85A_HUMAN (1-724): 0: 556: 94.35		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82
+	Mm
		140067 P85B_MOUSE (3-723): 3.36e-157: 474: 56.77		GAB2_MOUSE (1-665): 2.53e-180: 529: 99.85
+	Mm
		140061 P85B_MOUSE (3-723): 3.36e-157: 474: 56.77		Q3ZB59_MOUSE (1-665): 6.22e-180: 528: 100.00
+	Hs
		129351 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82
+	Mm
		643113 P85A_MOUSE (1-724): 0: 566: 100.00		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		655356 P85A_HUMAN (1-724): 0: 556: 94.35		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		129290 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		253434 SRGP2_HUMAN (116-668): 1.28e-60: 222: 14.14		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82
+	Hs
		64752 RHG32_HUMAN (14-523): 6.23e-58: 215: 14.79		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82
+	Hs
		506681 BCR_HUMAN (8-292): 8.41e-57: 212: 17.65		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82
+	Mm
		1193573 Q80UI5_MOUSE (328-724): 3.32e-96: 307: 100.00		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		1035395 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		64703 RHG32_HUMAN (14-523): 6.23e-58: 215: 14.79		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		1127521 RHG22_HUMAN (104-595): 8.45e-62: 221: 16.35		DOC11_HUMAN (9-448): 1.06e-63: 231: 16.21
+	Hs
		1132070 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		PKHS1_HUMAN (8-314): 1.04e-38: 151: 19.02
+	Hs
		253410 SRGP2_HUMAN (116-668): 1.28e-60: 222: 14.14		PKHA5_HUMAN (1-402): 1.93e-49: 188: 16.26
+	Hs
		253366 SRGP2_HUMAN (116-668): 1.28e-60: 222: 14.14		PKHA7_HUMAN (1-549): 2.93e-39: 157: 13.71
+	Hs
		200223 SRGP3_HUMAN (83-453): 5.8e-69: 247: 15.43		RHG24_HUMAN (3-117): 2.08e-12: 72.4: 28.23
+	Hs
		1191003 RHG22_HUMAN (104-595): 8.45e-62: 221: 16.35		DEFI6_HUMAN (8-114): 6.87e-15: 80.1: 25.23
+	Hs
		64723 RHG32_HUMAN (14-523): 6.23e-58: 215: 14.79		RHG24_HUMAN (3-117): 2.08e-12: 72.4: 28.23