HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: RASH (Q61411)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: Hras

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 24470255, 12196526
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ras~RhoGAP
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005829 - cytosol
GO:0008286 - insulin receptor signaling pathway
GO:0010628 - positive regulation of gene expression
GO:0030335 - positive regulation of cell migration
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
Mm

1 189
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024