HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 8702385, 22402124
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~SH2, FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006366 - transcription by RNA polymerase II
GO:0019901 - protein kinase binding
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024