HitPredict

Interactor 1: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	29721183
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly GO:0008584 - male gonad development GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 209 Hs			1 136
+	Hs
		449665 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		449674 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		449756 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		643320 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		643360 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		175769 HMGB3_HUMAN (13-176): 1.26e-39: 136: 70.73		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		175771 HMGB3_HUMAN (13-176): 1.26e-39: 136: 70.73		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		643358 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		935035 HMGB4_HUMAN (1-184): 1.7e-37: 130: 40.22		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		617322 SP100_HUMAN (25-174): 1.61e-31: 122: 74.67		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		952276 TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		449604 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		643268 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		727961 SOX11_HUMAN (3-98): 3.17e-19: 86.7: 23.47		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Sc
		514202 NHP6A_YEAST (75-164): 2.99e-25: 96: 44.44		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		935263 HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952640 HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Sc
		514265 NHP6B_YEAST (73-164): 5.93e-24: 92.9: 42.39		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Mm
		952739 SSRP1_MOUSE (4-84): 1.45e-14: 73.6: 35.80		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		828385 HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76