HitPredict

Interactor 1: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 209 Hs			1 292
+	Hs
		449545 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625125 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		414690 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		414748 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		414863 TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		414816 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		567641 UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		415030 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		841179 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24