HitPredict

Interactor 1: NKG2A (P26715)
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Gene: KLRC1

Interactor 2: CLC2D (Q9UHP7)
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Gene: CLEC2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~Lectin_C
Common GO terms	GO:0004888 - transmembrane signaling receptor activity GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0009897 - external side of plasma membrane GO:0030246 - carbohydrate binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 191
+	Hs
		644535 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		644622 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		KLRG1_HUMAN (26-186): 1.32e-36: 127: 20.61
+	Hs
		644632 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		CLC7A_HUMAN (20-187): 5.72e-36: 127: 20.00
+	Hs
		1129046 COL12_HUMAN (106-231): 4.95e-41: 150: 20.86		CLC2D_HUMAN (1-191): 2.05e-63: 196: 100.00
+	Hs
		644565 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		KLRD1_HUMAN (33-189): 2.76e-34: 121: 24.72
+	Hs
		644672 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		KLRD1_HUMAN (33-189): 2.76e-34: 121: 24.72
+	Hs
		530384 PGCB_HUMAN (12-233): 5.18e-51: 179: 18.64		CSPG2_HUMAN (52-189): 1.21e-42: 154: 20.67
+	Hs
		991248 NKG2E_HUMAN (1-225): 2.84e-67: 209: 69.03		KLRD1_HUMAN (33-189): 2.76e-34: 121: 24.72
+	Hs
		426840 CL17A_HUMAN (118-232): 3.67e-43: 151: 20.33		ASGR2_HUMAN (23-189): 1.21e-46: 156: 21.08
+	Hs
		1329767 CLC4M_HUMAN (95-232): 4.96e-43: 151: 21.48		CLC4M_HUMAN (72-188): 4.01e-45: 155: 28.68
+	Mm
		1208639 C209B_MOUSE (10-231): 2.92e-51: 170: 16.80		C209B_MOUSE (72-190): 2.15e-38: 135: 25.39
+	Hs
		59764 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		COL12_HUMAN (64-191): 1.25e-40: 147: 23.94
+	Hs
		1329768 CLC4M_HUMAN (95-232): 4.96e-43: 151: 21.48		CD209_HUMAN (72-188): 5.05e-43: 149: 30.23
+	Hs
		1170205 CL17A_HUMAN (118-232): 3.67e-43: 151: 20.33		CL17A_HUMAN (72-187): 1.27e-40: 142: 31.20
+	Hs
		644649 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		MRC2_HUMAN (87-184): 8.93e-09: 56.2: 21.50
+	Hs
		1129021 COL12_HUMAN (106-231): 4.95e-41: 150: 20.86		CL12A_HUMAN (48-191): 1.63e-34: 124: 23.33
+	Hs
		1129031 COL12_HUMAN (106-231): 4.95e-41: 150: 20.86		CLC4F_HUMAN (77-152): 6.03e-26: 105: 33.77