HitPredict

Interactor 1: NKG2C (P26717)
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
Gene: KLRC2

Interactor 2: KLRD1 (Q13241)
Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
Gene: KLRD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 8943374, 10320637, 18448674, 18083576, 32575403
Identification Methods affinity chromatography technology, surface plasmon resonance, blue native page
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Lectin_C~Lectin_C
Common GO terms GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002228 - natural killer cell mediated immunity
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
and 7 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 231
Hs

1 179
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024