HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: MICA (Q29983)
MHC class I polypeptide-related sequence A (MIC-A)
Gene: MICA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11323699, 21712812
Identification Methods	x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0009986 - cell surface GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 383
+	Hs
		1100221 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		MICB_HUMAN (1-382): 4.35e-141: 407: 82.72
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (19-340): 3.47e-137: 397: 27.49
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (19-340): 3.47e-137: 397: 27.49
+	Hs
		382490 CLC4D_HUMAN (42-212): 2.19e-39: 136: 16.75		HLAA_HUMAN (19-340): 3.47e-137: 397: 27.49
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (19-318): 8.11e-126: 368: 28.57
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (19-318): 8.11e-126: 368: 28.57
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (6-336): 7.7e-125: 365: 27.35
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (19-304): 1.97e-122: 359: 29.59
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (19-304): 1.97e-122: 359: 29.59
+	Hs
		354435 KLRD1_HUMAN (57-216): 5.29e-38: 131: 27.65		HLAB_HUMAN (19-318): 8.11e-126: 368: 28.57
+	Hs
		488317 CLC4D_HUMAN (42-212): 2.19e-39: 136: 16.75		HLAC_HUMAN (19-304): 1.97e-122: 359: 29.59
+	Hs
		488269 CLC4G_HUMAN (80-214): 7.27e-37: 132: 24.14		HLAC_HUMAN (19-304): 1.97e-122: 359: 29.59
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (19-321): 1.38e-118: 349: 29.26
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (19-321): 1.38e-118: 349: 29.26
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (19-340): 4.1e-117: 345: 27.49
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (19-340): 4.1e-117: 345: 27.49
+	Hs
		673960 CL12B_HUMAN (82-215): 4.91e-40: 139: 33.80		HLAF_HUMAN (19-340): 4.1e-117: 345: 27.49
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (26-325): 8.62e-34: 130: 27.39
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (26-325): 8.62e-34: 130: 27.39
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (26-325): 8.62e-34: 130: 27.39