HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: ULBP5 (Q6H3X3)
UL-16 binding protein 5 (Retinoic acid early transcript 1G protein)
Gene: RAET1G

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	18544572, 19424970, 19658097, 15240696
Identification Methods	enzyme linked immunosorbent assay, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 334
+	Hs
		644723 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP1_HUMAN (1-244): 5.62e-117: 339: 59.76
+	Hs
		644722 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP2_HUMAN (1-228): 1.1e-114: 334: 89.47
+	Hs
		644714 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP6_HUMAN (21-228): 3.35e-110: 322: 89.90
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (8-315): 2.4e-120: 352: 20.31
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (8-315): 2.4e-120: 352: 20.31
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (9-315): 6.52e-116: 341: 19.75
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (9-315): 1.14e-117: 344: 19.44
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (9-315): 6.52e-116: 341: 19.75
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (24-315): 1.35e-112: 332: 18.57
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (24-315): 1.35e-112: 332: 18.57
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (24-315): 5.23e-108: 320: 20.52
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (24-315): 5.23e-108: 320: 20.52
+	Hs
		644721 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP3_HUMAN (1-243): 2.39e-88: 266: 54.29
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (24-315): 2.94e-101: 303: 18.24
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (24-315): 2.94e-101: 303: 18.24
+	Mm
		139594 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		RAE1B_MOUSE (1-222): 1.13e-89: 270: 23.11
+	Hs
		644718 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		RAE1E_HUMAN (31-208): 3.64e-77: 238: 36.52
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (8-215): 2.56e-73: 231: 25.00
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (8-215): 2.56e-73: 231: 25.00
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (8-215): 2.56e-73: 231: 25.00