HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: RAE1E (Q8TD07)
Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4)
Gene: RAET1E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	28559451, 19436053, 19658097, 18544572
Identification Methods	surface plasmon resonance, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0042267 - natural killer cell mediated cytotoxicity GO:0045954 - positive regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 263
+	Hs
		644723 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP1_HUMAN (28-240): 1.99e-103: 302: 39.82
+	Hs
		644721 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP3_HUMAN (29-235): 5.24e-99: 291: 41.04
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (7-254): 2.28e-114: 334: 21.26
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (7-254): 2.28e-114: 334: 21.26
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (6-254): 1.83e-111: 327: 21.57
+	Hs
		644716 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP5_HUMAN (29-222): 4.36e-94: 281: 34.01
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (6-254): 1.83e-111: 327: 21.57
+	Hs
		644714 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP6_HUMAN (29-241): 3.36e-94: 278: 33.49
+	Hs
		644722 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP2_HUMAN (29-241): 1.86e-93: 276: 33.49
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (7-254): 1.54e-106: 314: 20.87
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (7-254): 1.54e-106: 314: 20.87
+	Mm
		139594 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		RAE1B_MOUSE (18-226): 6.1e-89: 265: 28.64
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (24-252): 1.73e-98: 293: 19.15
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (8-254): 5.4e-95: 284: 20.95
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (8-254): 5.4e-95: 284: 20.95
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (13-253): 1.95e-91: 275: 19.84
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (13-253): 1.95e-91: 275: 19.84
+	Hs
		644710 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		MICA_HUMAN (10-210): 5.3e-14: 72.8: 26.70
+	Mm
		222286 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		Q3TDZ7_MOUSE (29-247): 5.46e-13: 69: 20.51
+	Hs
		1100221 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		MICB_HUMAN (31-214): 3.92e-16: 79: 26.46