HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: ULBP2 (Q9BZM5)
UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)
Gene: ULBP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28559451, 19424970
Identification Methods	surface plasmon resonance, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0009986 - cell surface GO:0030101 - natural killer cell activation GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 246
+	Hs
		644716 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP5_HUMAN (1-228): 2.58e-105: 309: 89.47
+	Hs
		644723 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP1_HUMAN (1-245): 3.85e-91: 270: 59.59
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (24-245): 2.1e-104: 308: 19.48
+	Hs
		644714 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP6_HUMAN (21-246): 2.53e-88: 263: 96.46
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (24-245): 2.1e-104: 308: 19.48
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (24-245): 1.23e-102: 303: 19.91
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (24-245): 1.23e-102: 303: 19.91
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (4-245): 5.25e-102: 301: 20.32
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (24-245): 1.4e-99: 296: 19.91
+	Hs
		644721 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP3_HUMAN (1-246): 1.26e-83: 251: 53.85
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (24-245): 1.4e-99: 296: 19.91
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (24-245): 2.32e-96: 287: 21.65
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (24-245): 2.32e-96: 287: 21.65
+	Mm
		139594 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		RAE1B_MOUSE (1-226): 4.39e-85: 255: 25.00
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (24-245): 8.73e-89: 268: 19.91
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (24-245): 8.73e-89: 268: 19.91
+	Hs
		644718 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		RAE1E_HUMAN (28-246): 1.45e-70: 218: 32.42
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (12-231): 3.86e-74: 230: 25.22
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (12-231): 3.86e-74: 230: 25.22
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (12-231): 3.86e-74: 230: 25.22