HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: ULBP1 (Q9BZM6)
UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I)
Gene: ULBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28559451
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0030101 - natural killer cell activation GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 244
+	Hs
		644716 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP5_HUMAN (1-226): 2.06e-112: 327: 61.84
+	Hs
		644714 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP6_HUMAN (21-243): 1.53e-110: 319: 58.67
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (24-242): 8.75e-110: 321: 19.28
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (24-242): 8.75e-110: 321: 19.28
+	Hs
		644718 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		RAE1E_HUMAN (27-243): 1.68e-92: 274: 39.63
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (24-242): 1.02e-106: 314: 19.28
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (24-242): 1.02e-106: 314: 19.28
+	Hs
		644722 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP2_HUMAN (1-243): 1.18e-88: 264: 59.59
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (24-242): 2.84e-103: 305: 18.83
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (24-242): 2.84e-103: 305: 18.83
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (15-242): 4.32e-104: 306: 21.80
+	Hs
		644721 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP3_HUMAN (1-243): 2.4e-85: 255: 54.51
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (24-242): 1.35e-98: 293: 20.18
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (24-242): 1.35e-98: 293: 20.18
+	Mm
		139594 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		RAE1B_MOUSE (2-229): 2.44e-86: 258: 21.93
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (24-242): 4.19e-92: 276: 17.94
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (24-242): 4.19e-92: 276: 17.94
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (13-242): 1.45e-85: 259: 23.48
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (13-242): 1.45e-85: 259: 23.48
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (13-242): 1.45e-85: 259: 23.48