HitPredict

Interactor 1: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Interactor 2: CLCF1 (Q9UBD9)
Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
Gene: CLCF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	11285233, 26858303
Identification Methods	affinity chromatography technology, biochemical, surface plasmon resonance
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0008284 - positive regulation of cell population proliferation GO:0043524 - negative regulation of neuron apoptotic process GO:0097059 - CNTFR-CLCF1 complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 225
+	Hs
		265798 CRLF1_HUMAN (22-340): 1.86e-53: 184: 24.06		CLCF1_HUMAN (1-225): 5.91e-127: 359: 100.00
+	Mm
		291719 CNTFR_MOUSE (1-355): 8.43e-69: 222: 96.06		CTF2_MOUSE (36-208): 5.86e-67: 206: 29.78
+	Mm
		789690 LIFR_MOUSE (19-329): 1.14e-52: 190: 16.51		CTF2_MOUSE (36-208): 5.86e-67: 206: 29.78
+	Mm
		789693 LIFR_MOUSE (19-329): 1.14e-52: 190: 16.51		CTF1_MOUSE (40-205): 2.99e-59: 187: 27.59
+	Hs
		789675 LIFR_HUMAN (31-329): 2.83e-54: 194: 15.02		CTF1_HUMAN (40-205): 3.95e-39: 135: 22.67
+	Hs
		265772 CRLF1_HUMAN (22-340): 1.86e-53: 184: 24.06		CTF1_HUMAN (40-205): 3.95e-39: 135: 22.67
+	Mm
		949439 IL6RB_MOUSE (65-302): 4.69e-11: 66.3: 14.74		CTF2_MOUSE (36-208): 5.86e-67: 206: 29.78