Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 26186194, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~ecTbetaR2, PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0016310 - phosphorylation
GO:0017002 - activin receptor activity
and 5 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 513
Hs

1 567
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Last updated: 15 Jul 2024