HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: GDF2 (Q9UK05)
Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
Gene: GDF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	17311849, 22718755
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0030509 - BMP signaling pathway GO:0032924 - activin receptor signaling pathway GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060391 - positive regulation of SMAD protein signal transduction GO:0071773 - cellular response to BMP stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 429
+	Hs
		574181 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP7_HUMAN (51-428): 1.93e-115: 346: 23.54
+	Hs
		312997 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP10_HUMAN (53-429): 1.52e-114: 343: 41.78
+	Hs
		602925 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP6_HUMAN (18-428): 1.92e-107: 328: 26.39
+	Hs
		520070 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP2_HUMAN (26-429): 2.24e-106: 321: 25.72
+	Hs
		520099 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP4_HUMAN (29-429): 7.58e-104: 315: 26.76
+	Hs
		574203 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP7_HUMAN (51-428): 1.93e-115: 346: 23.54
+	Hs
		313007 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP10_HUMAN (53-429): 1.52e-114: 343: 41.78
+	Hs
		646022 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		GDF5_HUMAN (18-429): 3.64e-96: 299: 23.19
+	Hs
		602931 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP6_HUMAN (18-428): 1.92e-107: 328: 26.39
+	Hs
		520077 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP2_HUMAN (26-429): 2.24e-106: 321: 25.72
+	Mm
		646088 AVR2A_MOUSE (1-513): 1.26e-154: 452: 99.61		INHBA_MOUSE (26-428): 5.33e-87: 272: 18.56
+	Hs
		439881 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		INHBA_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		792920 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF5_HUMAN (18-429): 3.64e-96: 299: 23.19
+	Hs
		646064 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		NODAL_HUMAN (69-428): 3.32e-76: 242: 27.40
+	Hs
		439886 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		INHBA_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		59851 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		A4D1W7_HUMAN (26-428): 1.28e-85: 269: 18.56
+	Hs
		451817 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		INHBB_HUMAN (39-428): 2.84e-71: 232: 20.96
+	Hs
		155757 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF8_HUMAN (43-428): 1.13e-84: 265: 20.35
+	Hs
		312855 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF11_HUMAN (31-428): 2.02e-73: 237: 19.57
+	Hs
		451820 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		INHBB_HUMAN (39-428): 2.84e-71: 232: 20.96