HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30240640, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1242
+	Hs
		724526 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00
+	Hs
		724528 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00
+	Mm
		724581 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59
+	Dm
		955052 1433E_DROME (2-242): 6.77e-143: 401: 65.02		IRS1_DROME (6-914): 8.1e-87: 305: 18.00
+	Dm
		664678 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		IRS1_DROME (6-914): 8.1e-87: 305: 18.00
+	Hs
		151760 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24
+	Hs
		151714 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24
+	Hs
		151765 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24
+	Hs
		910201 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33
+	Hs
		647417 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33
+	Hs
		64684 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RHG32_HUMAN (302-1240): 1.06e-36: 153: 13.08
+	Hs
		64657 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RHG32_HUMAN (302-1240): 1.06e-36: 153: 13.08
+	Hs
		64689 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RHG32_HUMAN (302-1240): 1.06e-36: 153: 13.08
+	Hs
		909455 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ANK2_HUMAN (257-1242): 1.24e-31: 137: 12.26
+	Hs
		646808 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ANK2_HUMAN (257-1242): 1.24e-31: 137: 12.26
+	Hs
		926936 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ANK2_HUMAN (257-1242): 1.24e-31: 137: 12.26
+	Hs
		297821 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		K0754_HUMAN (811-1241): 1.63e-24: 114: 8.73
+	Hs
		297824 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		K0754_HUMAN (811-1241): 1.63e-24: 114: 8.73
+	Hs
		909712 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		OTOG_HUMAN (267-651): 8.41e-11: 69.2: 11.83
+	Hs
		647025 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		OTOG_HUMAN (267-651): 8.41e-11: 69.2: 11.83