HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	17353931, 36931259, 23444366
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1824
+	Hs
		876345 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		66891 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		A8MQ02_HUMAN (43-1824): 0: 1196: 99.44
+	Hs
		66892 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		A8MQ02_HUMAN (43-1824): 0: 1196: 99.44
+	Hs
		910062 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		647306 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Dm
		54781 1433E_DROME (2-242): 6.77e-143: 401: 65.02		A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76
+	Dm
		54779 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76
+	Hs
		909583 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		646906 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		231490 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66
+	Hs
		231455 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66
+	Mm
		910260 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		909912 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RADIL_HUMAN (830-1106): 4.06e-27: 122: 18.06
+	Mm
		926805 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		646881 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		909498 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Mm
		926868 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		MYO5A_MOUSE (1409-1824): 1.89e-18: 95: 14.81
+	Hs
		646848 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Mm
		926859 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		LNX2_MOUSE (973-1126): 6.83e-17: 88.9: 20.38
+	Hs
		646909 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67