HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 217
+	Hs
		909427 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924450 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		683253 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Dm
		954994 1433E_DROME (2-242): 6.77e-143: 401: 65.02		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Dm
		664604 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Hs
		411661 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411605 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411666 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		782766 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337416 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789053 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		782768 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337355 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		646706 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337420 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789056 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		683181 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337366 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		683185 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		275184 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62