HitPredict

Interactor 1: RHG32 (A7KAX9)
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Gene: ARHGAP32

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2087 Hs			1 192
+	Hs
		64688 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		64649 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		64741 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		64692 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		64680 RHG32_HUMAN (1-2087): 0: 1424: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Mm
		925803 RHG32_MOUSE (1-2087): 0: 1404: 87.28		RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71
+	Hs
		64681 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		64644 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		64652 RHG32_HUMAN (1-2087): 0: 1424: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Mm
		892730 RHG32_MOUSE (1-2087): 0: 1404: 87.28		CDC42_MOUSE (1-192): 3.66e-77: 230: 68.75
+	Hs
		147862 RHG33_HUMAN (74-1276): 2.2e-113: 395: 30.98		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Mm
		1194500 RHG33_MOUSE (73-1289): 3.48e-114: 398: 30.65		RHOJ_MOUSE (4-179): 5.7e-79: 236: 62.50
+	Mm
		892729 RHG33_MOUSE (73-1289): 3.48e-114: 398: 30.65		CDC42_MOUSE (1-192): 3.66e-77: 230: 68.75
+	Dm
		776916 CDGAP_DROME (76-1527): 1.83e-93: 339: 20.94		RAC1_DROME (1-192): 2.16e-81: 241: 89.06
+	Hs
		925314 RHG44_HUMAN (335-893): 3.16e-80: 286: 19.37		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		200213 SRGP3_HUMAN (294-939): 5.72e-78: 284: 17.36		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		894068 RHG44_HUMAN (335-893): 3.16e-80: 286: 19.37		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		893974 MYO9B_HUMAN (43-823): 2.74e-75: 281: 13.14		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900443 MYO9B_HUMAN (43-823): 2.74e-75: 281: 13.14		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436289 MYO9B_HUMAN (43-823): 2.74e-75: 281: 13.14		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79