HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	31980649, 35271311, 32707033, 36931259, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 393
+	Hs
		909461 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		647862 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Xl
		223344 O57468_XENLA (2-243): 4.53e-144: 404: 64.75		Q804T2_XENLA (1-333): 1.36e-120: 367: 19.94
+	Hs
		734905 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		625306 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		646650 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	At
		965360 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	Hs
		646688 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	At
		788672 14333_ARATH (3-243): 8e-143: 401: 61.63		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	At
		1280891 14337_ARATH (2-243): 2.78e-142: 400: 60.32		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	Hs
		625130 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		909447 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	At
		965298 14332_ARATH (3-243): 8.65e-144: 404: 61.22		MPK7_ARATH (67-383): 1.52e-119: 352: 18.71
+	Hs
		646799 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Hs
		909502 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Dm
		954998 1433E_DROME (2-242): 6.77e-143: 401: 65.02		DSOR1_DROME (12-392): 4.19e-114: 340: 61.42
+	Hs
		909512 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		STK3_HUMAN (50-369): 2.6e-109: 331: 33.23
+	Hs
		646852 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		153111 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49