HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: M3K10 (Q02779)
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)
Gene: MAP3K10

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 954
+	Hs
		909462 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K10_HUMAN (1-954): 0: 726: 100.00
+	Hs
		909438 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77
+	Hs
		646793 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77
+	Hs
		909655 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59
+	Hs
		646976 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59
+	Hs
		789053 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL2_HUMAN (5-935): 7.45e-135: 436: 17.33
+	Hs
		646706 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL2_HUMAN (5-935): 7.45e-135: 436: 17.33
+	Hs
		909795 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ULK2_HUMAN (97-884): 2.01e-132: 426: 18.53
+	Hs
		337416 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ABL1_HUMAN (5-950): 1.72e-126: 412: 18.02
+	Hs
		910094 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K20_HUMAN (89-897): 1.97e-127: 406: 21.34
+	Hs
		337355 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ABL1_HUMAN (5-950): 1.72e-126: 412: 18.02
+	Mm
		910278 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		TAOK2_MOUSE (71-915): 4.41e-120: 397: 15.39
+	At
		965327 14332_ARATH (3-243): 8.65e-144: 404: 61.22		PBS1_ARATH (28-463): 5.24e-127: 393: 20.52
+	Hs
		909810 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MINK1_HUMAN (98-925): 6.77e-114: 382: 16.47
+	Hs
		646845 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K12_HUMAN (80-836): 1e-119: 387: 27.17
+	At
		965320 14332_ARATH (3-243): 8.65e-144: 404: 61.22		BAK1_ARATH (58-410): 8.93e-120: 380: 23.16
+	At
		788521 14333_ARATH (3-243): 8e-143: 401: 61.63		PBL9_ARATH (53-362): 1.21e-119: 372: 22.77
+	Hs
		411661 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		LCK_HUMAN (2-372): 3.86e-113: 359: 25.00
+	Hs
		411605 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		LCK_HUMAN (2-372): 3.86e-113: 359: 25.00
+	Hs
		201290 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K7_HUMAN (83-355): 2.87e-45: 175: 38.49