HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	10620507
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016020 - membrane GO:0070062 - extracellular exosome and 1 others more... GO:0071889 - 14-3-3 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 592
+	Hs
		926956 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCZ_HUMAN (1-592): 0: 688: 100.00
+	Hs
		783970 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		646701 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		783973 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		926957 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Hs
		681770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		681776 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		568616 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		647354 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KS6B2_HUMAN (237-590): 1.59e-143: 425: 36.59
+	Hs
		116972 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SGK1_HUMAN (199-583): 7.41e-144: 424: 38.36
+	Hs
		116995 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SGK1_HUMAN (199-583): 7.41e-144: 424: 38.36
+	Hs
		568620 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		646741 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47
+	Hs
		909458 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		646812 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		926942 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		566293 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		566348 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		646820 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		KPCT_HUMAN (115-202): 1.47e-13: 75.7: 29.55
+	Hs
		397155 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		KPCG_HUMAN (116-180): 1.87e-10: 65.9: 36.92