HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: FOXO1 (Q12778)
Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
Gene: FOXO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	24419059, 33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 655
+	Hs
		909490 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FOXO1_HUMAN (1-655): 2.55e-104: 332: 100.00
+	Hs
		926976 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		FOXO1_HUMAN (1-655): 2.55e-104: 332: 100.00
+	Hs
		206820 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		206799 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		206822 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		206807 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		46292 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		A0A1X9RU27_HUMAN (80-655): 3.14e-62: 218: 30.99
+	Hs
		46293 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		A0A1X9RU27_HUMAN (80-655): 3.14e-62: 218: 30.99
+	Hs
		909442 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		909439 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		909499 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FOXC1_HUMAN (120-282): 1.05e-43: 167: 31.33
+	Hs
		646796 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		926923 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		926921 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		683265 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Dm
		955013 1433E_DROME (2-242): 6.77e-143: 401: 65.02		FOXO_DROME (88-470): 3.72e-39: 154: 34.27
+	Dm
		664627 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		FOXO_DROME (88-470): 3.72e-39: 154: 34.27
+	Hs
		683226 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		FOXA1_HUMAN (31-448): 1.67e-37: 147: 16.20
+	Hs
		68643 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		FOXO6_HUMAN (535-655): 1.92e-11: 68.7: 27.64
+	Hs
		68644 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		FOXO6_HUMAN (535-655): 1.92e-11: 68.7: 27.64