HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: PDE3A (Q14432)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Gene: PDE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	23444366, 15161933
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 1141
+	Hs
		927039 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		909520 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		646867 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		927008 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		981979 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		904523 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Mm
		926778 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		PDE4D_MOUSE (394-1074): 1.01e-177: 541: 21.92
+	Mm
		926779 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		PDE1B_MOUSE (516-1127): 3.99e-148: 456: 23.21
+	Mm
		926801 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		PDE1A_MOUSE (614-1125): 3.79e-134: 420: 24.29
+	Hs
		872399 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PDE1A_HUMAN (614-1106): 4.53e-134: 420: 25.20
+	Hs
		909546 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		927028 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		910054 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		683334 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		647301 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		927558 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		683736 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		905142 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85